Laura Segatori, Ph.D.

Professor of Bioengineering

segatori@rice.edu

Laura Segatori develops innovative, system-level strategies based on the integration of synthetic biology, protein engineering, and bionanotechnology to reprogram the cellular quality control system in mammalian cells. The approaches allow for a broader understanding and control over the molecular mechanisms that regulate protein processing for applications ranging from development of cell-based therapies to the production of biologics.

For nearly two decades, Segatori’s research efforts have focused on understanding and characterizing the elaborate molecular and cellular pathways that cope with protein misfolding. To this end, the Segatori group combines experimental approaches and predictive modeling to create genetic circuits that perturb and reprogram innate cellular pathways that mediate protein processing and promote degradation and recycling of aberrant cellular components.